Treating Intracranial Abscesses in Rats with Stereotactic Injection of Biodegradable Vancomycin-Embedded Microparticles

Autor:	Yuan-Yun Tseng, Ching-Wei Kao, Kuo-Sheng Liu, Ya-Ling Tang, Yen-Wei Liu, Shih-Jung Liu
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	brain abscess stereotactic poly(lactide-co-glycolide acid) electrospraying drug delivery vancomycin Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceutics, Vol 12, Iss 2, p 91 (2020)
Druh dokumentu:	article
ISSN:	1999-4923
DOI:	10.3390/pharmaceutics12020091
Popis:	Brain abscesses are emergent and life-threating despite advances in modern neurosurgical techniques and antibiotics. The present study explores the efficacy of vancomycin embedded to 50:50 poly(lactic-co-glycolide acid) (PLGA) microparticles in the treatment of brain abscess. The vancomycin embedded microparticles (VMPs) were stereotactically introduced into the cerebral parenchyma in Staphylococcus aureus bacteria- induced brain abscess-bearing rats. Experimental rats were divided into three groups: group A (n = 13; no treatment), group B (n = 14; daily vancomycin injection (5 mg intraperitoneally), and group C (n = 12; stereotactic introduction of VMPs into the abscess cavity). Group C exhibited no inflammatory response and significantly increased survival and reduced mean abscess volumes (p
Databáze:	Directory of Open Access Journals
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