Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry

Autor: Michal Bassani-Sternberg, Eva Bräunlein, Richard Klar, Thomas Engleitner, Pavel Sinitcyn, Stefan Audehm, Melanie Straub, Julia Weber, Julia Slotta-Huspenina, Katja Specht, Marc E. Martignoni, Angelika Werner, Rüdiger Hein, Dirk H. Busch, Christian Peschel, Roland Rad, Jürgen Cox, Matthias Mann, Angela M. Krackhardt
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms13404
Popis: Neoantigens determine anti-cancer immunoreactivity and are important functional targets for immunotherapy. Here, the authors use deep mass spectrometry to characterize neoepitopes from human melanoma tissue and show the presence of tumour-reactive T cells with specificity for selected neoantigens.
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