Clinical and Laboratory Evaluation of Patients Diagnosed with COVID-19 Receiving Favipiravir-based Treatment

Autor: Burak SARIKAYA, Semiha ÇELİK EKİNCİ
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Bezmiâlem Science, Vol 8, Iss 3, Pp 67-73 (2020)
Druh dokumentu: article
ISSN: 2148-2373
DOI: 10.14235/bas.galenos.2020.4889
Popis: Objective:Severe acute respiratory syndrome coronavirus-2 (SARS COV-2); can lead to severe respiratory failure. In this study, factors affecting mortality in Coronavirus disease (COVID-19) patients who were hospitalized with hydroxychloroquine (HCQ), azithromycin and favipiravir treatments were investigated.Methods:Between March 10 and May 10, 2020, COVID-19 reverse transcription polymerase chain reaction (RT-PCR) positive treatment naive 683 patients were screened retrospectively. Five hundred four patients were followed without treatment or with HCQ treatment. Out of 179 patients, 137 were hospitalized and 42 were directly admitted to the intensive care unit (ICU). Oxygen saturation of these patients is 30/min) and HCQ, azithromycin, favipiravir were started. 35 of 137 patients were transferred to ICU. Mechanical ventilation was provided to 69 (89%) of 77 patients in the ICU. 19 (24%) patients received tosilizumab and 13 (17%) patients received immune plasma. It was divided into two as healing and exitus. Demographic features, comorbid diseases, secondary bacterial infections and acute organ damage were recorded.Results:Two hundred of the patients were male and their average age was 60.9±16.4 years. HT and diabetes mellitus (DM) were the most common comorbid disease. Acute liver injury was most common. 54 patients became exitus. Exitus group has higher mean age, chronic heart disease (CHD), DM, CRF, acute cardiac damage and secondary bacterial infection are more statistically significant (p
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