Irisin plays an important role in the outcomes of newly diagnosed prediabetes in adults in Guiyang, China
| Autor: | Xi He, Qiao Zhang, Nianchun Peng, Ying Hu, Hong Li, Zhengyi Chen, Ruoyi Liu, Shujing Xu, Miao Zhang, Juan He, Lixin Shi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Diabetes Investigation, Vol 12, Iss 5, Pp 747-755 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2040-1124 2040-1116 |
| DOI: | 10.1111/jdi.13416 |
| Popis: | Abstract Aims/Introduction To explore the potential role of irisin in the outcomes of newly diagnosed prediabetes. Materials and Methods Data were obtained from the Guiyang subcenter of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study. A total of 2,530 participants had newly diagnosed prediabetes at baseline and completed follow up. The nested 1:1 case–control study included 161 participants who developed diabetes mellitus at follow up, and 161 age‐ and sex‐matched controls. The follow‐up study included 86 matched case–control pairs. Fasting serum irisin levels were measured using enzyme‐linked immunosorbent assay. Results Baseline serum irisin levels were higher in the cases than in the controls (P = 0.002); high baseline serum irisin levels were an independent risk factor for the development of diabetes (odds ratio 1.235, 95% confidence interval 1.025–1.488). After adjustment for age, sex, body mass index, glycated hemoglobin (HbA1c), smoking, exercise, and family history of diabetes, subjects in the highest quartile of irisin levels had a higher risk of diabetes than those in the lowest quartile (odds ratio 3.065, 95% confidence interval 1.511–6.218). The extent of decrease in irisin levels during follow‐up was greater in the cases than in the controls (P |
| Databáze: | Directory of Open Access Journals |
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