| Autor: |
Wenwu Wang, Likun Chang, Yichun Shao, Dan Yu, Jayanti Parajuli, Chao Xu, Guoliang Ying, Ali K. Yetisen, Yixia Yin, Nan Jiang |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Engineered Regeneration, Vol 3, Iss 1, Pp 1-12 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2666-1381 |
| DOI: |
10.1016/j.engreg.2022.01.007 |
| Popis: |
ABSTRACT: To regulate cell behaviors and promote nerve function recovery, three-dimensional (3D) conductive hydrogel can transmit intercellular electrical signals, and effectively provide the cell survival environment. However, producing hydrogels with simultaneous high conductivity, favorable biocompatibility, and tissue-matching properties remains a challenge for spinal cord injury (SCI) treatment. Here, a conductive, multifunctional, and biocompatible VPImBF4 ionic liquid (IL) with photosensitive chitosan-based hydrogel (pCM@IL) is developed. The pCM@IL hydrogel exhibits a 3D microporous structure that could maintain cell viability and improve cell growth. Elastic modulus, conductivity, and biodegradability of the pCM@IL hydrogels are investigated with tissue-matching mechanical properties. The pCM@IL conductive hydrogels synergistically enhance neuronal cell proliferation and promote neuronal cells differentiation via upregulates synapse gene (Tubulin β3, GAP43, Synaptophysin) expression. Furthermore, in vivo studies of the pCM@IL conductive hydrogels as implants demonstrate low-inflammation and neovascularize promotion and appropriate biodegradable properties. The developed pCM@IL conductive hydrogel is a promising therapeutic scaffold biomaterial for SCI repair. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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