| Autor: |
Xiaohua Li, Weiyi Wang, Qiuqin He, Yin Liu, Renhua Fan |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Green Synthesis and Catalysis, Vol 3, Iss 3, Pp 282-286 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2666-5549 |
| DOI: |
10.1016/j.gresc.2022.01.001 |
| Popis: |
Chiral N-alkylated indoles are privileged structural motifs found in many natural products and pharmaceuticals and a search for effective methods with which to prepare chiral N-alkylated indoles is ongoing. Efficient syntheses of enantioenriched N-alkylated indoles has been developed but not with standing these advances, the development of a facile method to prepare chiral N-alkylated indoles from simple and available starting materials under mild conditions is still needed. In this paper, we report a nitrogen replacement process driven by dearomatization that directly incorporates natural α-amino acids into 2-alkynylanilines leading to the formation of a variety of multi-functional chiral N-alkylated indoles. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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