Impaired cytotoxicity associated with defective natural killer cell differentiation in myelodysplastic syndromes
| Autor: | Maryam Hejazi, Angela R. Manser, Julia Fröbel, Andrea Kündgen, Xiaoyi Zhao, Kathrin Schönberg, Ulrich Germing, Rainer Haas, Norbert Gattermann, Markus Uhrberg |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Haematologica, Vol 100, Iss 5 (2015) |
| Druh dokumentu: | article |
| ISSN: | 0390-6078 1592-8721 42048109 |
| DOI: | 10.3324/haematol.2014.118679 |
| Popis: | Natural killer cells are well known to mediate anti-leukemic responses in myeloid leukemia but their role in myelodysplastic syndromes is not well understood. Here, in a cohort of newly diagnosed patients (n=75), widespread structural and functional natural killer cell defects were identified. One subgroup of patients (13%) had a selective deficiency of peripheral natural killer cells (count |
| Databáze: | Directory of Open Access Journals |
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