Biodentine stimulates the migratory and biological responses of human gingival fibroblast

Autor: Febe Vázquez-Vázquez, Alejandra Rodríguez-Hidalgo, Fernando Suaste-Olmos, Patricia González-Alva, Marco Alvarez-Perez
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Oral Research, Vol 11, Iss 2, Pp 1-14 (2022)
Druh dokumentu: article
ISSN: 0719-2460
0719-2479
DOI: 10.17126/joralres.2022.019
Popis: Introduction: Biodentine (BD), a dentin substitute, is currently used to treat external cervical root resorption, but its effects on gingival fibroblasts (GFs) are not fully known. Objective: To investigate and compare BD and MTA (mineral trioxide aggre-gate) in terms of proliferative, migratory, and adhesion effects on human pulpal and gingival cells. Material and Methods: Cells were incubated directly on the surface of BD and MTA disks. Adhesion (4 and 24 h) and proliferation (3, 5, 7, 14, 21) were evaluated with crystal violet and MTT assays (n=9 X each group). A wound-healing assay was performed for cell migration, with 0.2 and 2 µg/ml MTA or BD (n=6 X each group). The cut-off point for statistical significance was set at p
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