Preventive effect of taurine on experimental type II diabetic nephropathy
| Autor: | Lin Shumei, Yang Jiancheng, Wu Gaofeng, Liu Mei, Luan Xinhong, Lv Qiufeng, Zhao He, Hu Jianmin |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Journal of Biomedical Science, Vol 17, Iss Suppl 1, p S46 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1423-0127 1021-7770 |
| DOI: | 10.1186/1423-0127-17-S1-S46 |
| Popis: | Abstract Background It has been verified that taurine has some preventive effects on diabetes and its complications when used alone or together with other drugs, but there are few reports about taurine on the prevention of diabetic nephropathy, the mechanisms of which are still unknown. Methods Taurine was administered to type Ⅱ diabetic rats induced by high fat high sugar diet combined with STZ injection. The preventive effect of taurine on diabetic nephropathy was investigated by detecting blood glucose, lipid metabolism, kidney function and glomerular basement membrane metabolism. Results Taurine could lower blood glucose, TG, TC, BUN, Scr, NAG, U-PRO, the expression of laminin B1( LBN1) mRNA, and increase HDL-C of diabetic rats. Conclusions The results indicated that taurine could prevent the occurrence and development of diabetic nephropathy by decreasing blood glucose, improving lipid metabolism, glomerular basement membrane metabolism, and kidney function. |
| Databáze: | Directory of Open Access Journals |
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