Application of Animal Models in Interpreting Dry Eye Disease
| Autor: | Jun Zhu, Takenori Inomata, Kendrick Co Shih, Yuichi Okumura, Kenta Fujio, Tianxiang Huang, Ken Nagino, Yasutsugu Akasaki, Keiichi Fujimoto, Ai Yanagawa, Maria Miura, Akie Midorikawa-Inomata, Kunihiko Hirosawa, Mizu Kuwahara, Hurramhon Shokirova, Atsuko Eguchi, Yuki Morooka, Fang Chen, Akira Murakami |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Frontiers in Medicine, Vol 9 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2296-858X 78123836 |
| DOI: | 10.3389/fmed.2022.830592 |
| Popis: | Different pathophysiologic mechanisms are involved in the initiation, development, and outcome of dry eye disease (DED). Animal models have proven valuable and efficient in establishing ocular surface microenvironments that mimic humans, thus enabling better understanding of the pathogenesis. Several dry eye animal models, including lacrimal secretion insufficiency, evaporation, neuronal dysfunction, and environmental stress models, are related to different etiological factors. Other models may be categorized as having a multifactorial DED. In addition, there are variations in the methodological classification, including surgical lacrimal gland removal, drug-induced models, irradiation impairment, autoimmune antibody-induced models, and transgenic animals. The aforementioned models may manifest varying degrees of severity or specific pathophysiological mechanisms that contribute to the complexity of DED. This review aimed to summarize various dry eye animal models and evaluate their respective characteristics to improve our understanding of the underlying mechanism and identify therapeutic prospects for clinical purposes. |
| Databáze: | Directory of Open Access Journals |
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