Bone Mineral Density among adolescent's patients with β-thalassemia major.
| Autor: | Samar Abbas Jaffri, Syed Muhammad Irfan, Sadia Sultan, Syed Muhammad Usman, Sheeza Nadeem |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | International Journal of Endorsing Health Science Research, Vol 9, Iss 1, Pp 42-47 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2307-3748 2310-3841 |
| DOI: | 10.29052/IJEHSR.v9.i1.2021.42-47 |
| Popis: | Background:Beta-thalassemia is an autosomal recessivehemoglobinopathy with frequent skeletal complications, often debilitating in adolescent patients. We aim to evaluate the bone mineral density (BMD) by dual-energy x-ray absorptiometry (DEXA) and ascertain osteoporosis/osteopenia frequency in patients with β-thalassemia major. Methodology:In this cross-sectional study, 36 adolescent patients with β-thalassemia major were enrolled from June 2015 to March 2017. BMD was measured in the anteroposterior lumbar spine (L1-L4) and femoral neck by DEXA. For the biochemical estimations, blood and urine samples were obtained and analyzed. The results of a bone density test were presented as T and Z scores. Results:There were 20 male and 16 female patients with a mean age of 21.33 ± 3.7 years. The mean bone mineral content (BMC) was 20.10 ± 6.0 gm, and the mean BMD was0.65 ± 0.07 gm/cm2. The mean T score was -3.17 ± 1.04, and the Z score was -3.06 ± 1.06. All patients had low BMD, as depicted by their T or Z scores. The reported frequency of osteoporosis and osteopenia was 77.7% and 22.2%, respectively. Conclusion:All Beta-thalassemia major patients had low BMD with a remarkable incidence of osteoporosis. It is recommended to perform an annual BMD among thalassemic patients to prevent fatal consequences and achieve an optimal bone density among such patients. |
| Databáze: | Directory of Open Access Journals |
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