Transdermal permeation of curcumin promoted by choline geranate ionic liquid: Potential for the treatment of skin diseases

Autor: Rodrigo Boscariol, José M. Oliveira Junior, Denicezar A. Baldo, Victor M. Balcão, Marta M.D.C. Vila
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Saudi Pharmaceutical Journal, Vol 30, Iss 4, Pp 382-397 (2022)
Druh dokumentu: article
ISSN: 1319-0164
DOI: 10.1016/j.jsps.2022.01.023
Popis: The transdermal permeation of curcumin aided by choline and geranic acid ionic liquid (CAGE-IL) was addressed as a potential treatment for skin diseases. An in-depth analysis of the effect of CAGE-IL concentration in the enhancement of transdermal permeation of curcumin was performed, and the results were modelled via nonlinear regression analysis. The results obtained showed that a low percentage of CAGE-IL (viz. 2.0%, w/w) was effective in disrupting the skin structure in a transient fashion, facilitating the passage of curcumin dissolved in it.
Databáze: Directory of Open Access Journals