| Autor: |
Takeshi Yamashita, MD, Akiko Sekiguchi, MD, Shinya Suzuki, MD, Takayuki Ohtsuka, MD, Koichi Sagara, MD, Hiroaki Tanabe, MD, Takashi Kunihara, MD, Hitoshi Sawada, MD, Tadanori Aizawa, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Journal of Arrhythmia, Vol 31, Iss 2, Pp 78-82 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1880-4276 |
| DOI: |
10.1016/j.joa.2014.07.003 |
| Popis: |
Background: Enlargement of the left atrium (LA) is a risk factor of atrial fibrillation (AF) recurrence after pharmacological and nonpharmacological interventions for AF. However, structural changes associated with LA enlargement have not been fully elucidated. Methods: To examine inflammation in the structural changes associated with LA enlargement, human left appendages obtained from 27 patients who underwent cardiac surgery by using the maze procedure were subjected to immunohistochemical analysis. Results: The extent of interstitial fibrosis increased according to the increase in LA dimension (LAD) as assessed by using ultrasound echocardiography. The extent of the infiltration of CD68-positive macrophages and CD3-positive T cells increased simultaneously according to the increments in LAD. The areas infiltrated by immune cells were positively and significantly correlated with LAD (r2=0.58, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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