Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2
| Autor: | Michele Cennamo, Evelina La Civita, Laura Sarno, Gianluigi Carbone, Sarah Di Somma, Serena Cabaro, Jacopo Troisi, Angelo Sirico, Francesco Paolo Improda, Maurizio Guida, Daniela Terracciano, Giuseppe Portella |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Microorganisms, Vol 11, Iss 1, p 223 (2023) |
| Druh dokumentu: | article |
| ISSN: | 11010223 2076-2607 |
| DOI: | 10.3390/microorganisms11010223 |
| Popis: | COVID-19 is characterized by the immune system’s overreaction resulting in a ‘cytokine storm’, consisting in a massive release of cytokine into the bloodstream, leading to local and systemic inflammatory response. This clinical picture is further complicated in case of infection of patients with a peculiar immunological status, such as pregnancy. In this paper, we focused on Interferon-γ, which plays a pivotal immunomodulatory role in normal pregnancy and fetal development, as well as in defense against pathogens. In this study, we compared the levels of Interferon-γ and the Interferon autoantibodies of the peripheral and cord blood of pregnant women with confirmed mild COVID-19 and healthy pregnant women. The Interferon-γ was significantly lower both in the peripheral and cord blood of SARS-CoV-2-positive mothers, suggesting that infection can affect the fetal microenvironment even without severe maternal symptoms. In conclusion, further studies are needed to clarify whether lower levels of Interferon-γ due to SARS-CoV-2 infection affect the development or infection susceptibility of infants born to SARS-CoV-2-infected mothers. |
| Databáze: | Directory of Open Access Journals |
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