Analgesic effect of chronic oral administration of aerial part of Marrubium Vulgare in diabetic rats
| Autor: | M Roghani,, T Balouch Nejad Mojarad |
|---|---|
| Jazyk: | English<br />Persian |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 8, Iss 2, Pp 7-13 (2006) |
| Druh dokumentu: | article |
| ISSN: | 1561-4107 2251-7170 |
| Popis: | BACKGROUND AND OBJECTIVE: Considering the antidiabetic and anti-inflammatory effect of marrubium vulgare (MV), this study was designed to investigate the analgesic effect of MV on formalin-induced nociceptive response (standard formalin test) in diabetic rats. METHODS: Forty-eight rats were randomly divided into control, MV-treated control, diabetic, sodium salicylate (SS)-treated diabetic, sodium salicylate (SS)-treated control and MV-treated diabetic groups. For induction of diabetes, streptozotocin was used at a single dose. The treatment groups received oral administration of MV-mixed pelleted food (6.25%) for two months. FINDINGS: In this study, administration of sodium salicylate to control and diabetic groups caused a significant reduction in pain score in the second phase of formalin test (p |
| Databáze: | Directory of Open Access Journals |
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