Effect of Zinc Oxide Nanoparticles on The Spleen of Adult Male Albino Rat and The Possible Protective Role of Selenium: Microanatomical and Biochemical Study.
| Autor: | Sara Abd El fadeel, Hanan Yassa, Laila Rashed, Gaber Abd El Fattah |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Egyptian Journal of Medical Research, Vol 3, Iss 3, Pp 87-104 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2682-4396 2682-440X |
| DOI: | 10.21608/ejmr.2022.253797 |
| Popis: | Thirty five adult male albino rats were used in this study. They were divided into 7 groups: Group I (Control), Group II (low dose Zno NPs group) , Group III (medium dose Zno NPs group) , Group IV (high dose Zno NPs group), Group V (low dose Zno NPs-selenite group), Group VI (medium dose Zno NPs-selenite group), Group VII (high dose Zno NPs-selenite group): tissue of the spleen was examined histopathologically and immunohistochemical , Determination of blood cells count (number of white blood cells (WBCs), red blood corpuscles (RBCs) and platelets. Also tissue level of Hydrogen peroxide (H2O2) and paraoxonase-1(pon-1): for detection of oxidative stress estimated for all groups, PCR detection of apoptosis inducing factor (AIF), apoptotic protease activating factor-1 and caspases 3 and Zinc level in the spleen. Results of the present study showed that, compared to controls: orally intake of Zinc oxide nanoparticles (Zno NPs) cause marked changes in spleen tissues as thickening of capsule, thickening of trabeculae , destruction of white pulp and red pulp expansion especially in groups receiving zinc oxide nanoparticles only and these changes markedly decreased on groups receiving selenium as protection |
| Databáze: | Directory of Open Access Journals |
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