Expression of CREBBP and EP300 Associated With Tumor Volume in Patients With Grade-3 Glioma: A Retrospective Analysis
| Autor: | Cuiwei Chen, Meiqin Yuan, Liang Xia, Xin Wu, Xingguang Zhong, Huangjie Zhang, Lidan Zhang, Xuan Liu, Zeng Wang, Caixing Sun |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Clinical Medicine Insights: Oncology, Vol 18 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1179-5549 11795549 |
| DOI: | 10.1177/11795549241287777 |
| Popis: | Background: Reliable predictive data are crucial for making accurate treatment decisions in glioma patients, but it can be challenging to obtain due to limited information in many cases. Numerous research studies have indicated the involvement of cyclic adenosine monophosphate (cAMP)-response element binding protein (CREBBP) and E1A binding protein p300 (EP300) in tumorigenesis and tumor progression across various types. Methods: The messenger RNA (mRNA) expression levels of CREBBP and EP300 were retrospectively analyzed in 17 grade-3 glioma patients. The SYBR Green real-time polymerase chain reaction (RT-PCR) technique was employed for mRNA expression analysis, with the glyceraldehyde-3-phosphate dehydrogenase gene ( GAPDH ) used as a reference gene for data normalization. In addition, the relationship between CREBBP, EP300 expression and patients’ clinical information, imaging features, histologic features, immune factors, and overall survival was assessed through univariate analyses. Results: The analysis of the data unveiled a statistically significant upregulation of CREBBP and EP300 mRNA expression levels in large gliomas as compared with their smaller counterparts ( P |
| Databáze: | Directory of Open Access Journals |
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