Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles

Autor:	Manuel Bañó-Polo, Luis Martínez-Gil, Manuel M. Sánchez del Pino, Alberto Massoli, Ismael Mingarro, Rubén Léon, Maria Jesus Garcia-Murria
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	sars-cov-2 cetylpyridinium chloride virology virus-like particles membrane disaggregation Infectious and parasitic diseases RC109-216 Microbiology QR1-502
Zdroj:	Journal of Oral Microbiology, Vol 14, Iss 1 (2022)
Druh dokumentu:	article
ISSN:	2000-2297 20002297
DOI:	10.1080/20002297.2022.2030094
Popis:	Background SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory. Aim of the study To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor. Methods SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations. Results Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes. Conclusion Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/986436ed09c94f63ad5cf2a601d8b1cf Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF