Associations of plasma phospholipid cis-vaccenic acid with insulin resistance markers in non-diabetic men with hyperlipidemia

Autor: Jaroslav Macášek, Barbora Staňková, Aleš Žák, Markéta Růžičková, Radan Brůha, Simona Kutová, Marek Vecka, Miroslav Zeman
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Nutrition & Diabetes, Vol 14, Iss 1, Pp 1-8 (2024)
Druh dokumentu: article
ISSN: 2044-4052
98412159
DOI: 10.1038/s41387-024-00332-z
Popis: Abstract Background The role of fatty acids (FA) in the pathogenesis of insulin resistance and hyperlipidemia is a subject of intensive research. Several recent works have suggested cis-vaccenic acid (cVA) in plasma lipid compartments, especially in plasma phospholipids (PL) or erythrocyte membranes, could be associated with markers of insulin sensitivity and cardiovascular health. Nevertheless, not all the results of research work testify to these beneficial effects of cVA. Therefore, we decided to investigate the relations of proportion of cVA in plasma PL to markers of insulin resistance in hyperlipidemic men. Subjects In 231 men (median age 50) with newly diagnosed hyperlipidemia, we analyzed basic clinical parameters together with FA composition of plasma PL and stratified them according to the content of cVA into upper quartile (Q4) and lower quartile (Q1) groups. We examined also small control group of 50 healthy men. Results The individuals in Q4 differed from Q1 by lower plasma insulin (p
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