Complete Response of Triple-Negative Metaplastic Carcinoma of the Breast Using Pembrolizumab

Autor:	Amrita Ladwa, Omar Elghawy, Anneke Schroen, Kristan Abernathy, Jenna Schlefman, Patrick Dillon
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	metaplastic breast cancer immunotherapy triple-negative metaplastic breast cancer pembrolizumab case report Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Case Reports in Oncology, Vol 16, Iss 1, Pp 1129-1135 (2023)
Druh dokumentu:	article
ISSN:	1662-6575 00053414
DOI:	10.1159/000534146
Popis:	Metaplastic breast cancer (MpBC) is a rare form of breast malignancy with a poor prognosis and limited treatment guidance. Here, we report on a case of triple-negative MpBC that was successfully treated following the Keynote-522 clinical algorithm using pembrolizumab, paclitaxel, carboplatin, adriamycin, and cyclophosphamide in a neo-adjuvant fashion. The radiographic and histologic findings of the tumor are reviewed here along with the treatment regimen and response. No major toxicities associated with pembrolizumab were observed in this case. This case report serves as an example of complete pathological response of triple-negative MpBC with pembrolizumab plus chemotherapy and demonstrates the need for further research on chemoimmunotherapy for MpBC.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9836f39374b74ab0b834f4800f251e9e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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