Differences of survival benefits brought by various treatments in ovarian cancer patients with different tumor stages

Autor: Tingshan He, Hong Li, Zhiqiao Zhang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-16 (2023)
Druh dokumentu: article
ISSN: 1757-2215
DOI: 10.1186/s13048-023-01173-7
Popis: Abstract Purpose The current study aimed to explore the prognosis of ovarian cancer patients in different subgroup using three prognostic research indexes. The current study aimed to build a prognostic model for ovarian cancer patients. Methods The study dataset was downloaded from Surveillance Epidemiology and End Results database. Accelerated Failure Time algorithm was used to construct a prognostic model for ovary cancer. Results The mortality rate in the model group was 51.6% (9,314/18,056), while the mortality rate in the validation group was 52.1% (6,358/12,199). The current study constructed a prognostic model for ovarian cancer patients. The C indexes were 0.741 (95% confidence interval: 0.731–0.751) in model dataset and 0.738 (95% confidence interval: 0.726–0.750) in validation dataset. Brier score was 0.179 for model dataset and validation dataset. The C indexes were 0.741 (95% confidence interval: 0.733–0.749) in bootstrap internal validation dataset. Brier score was 0.178 for bootstrap internal validation dataset. Conclusion The current research indicated that there were significant differences in the survival benefits of treatments among ovarian cancer patients with different stages. The current research developed an individual mortality risk predictive system that could provide valuable predictive information for ovarian cancer patients. Graphical Abstract
Databáze: Directory of Open Access Journals
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