| Autor: |
Alicia K. Peterson, Sandrah P. Eckel, Rima Habre, Tingyu Yang, Dema Faham, Monica Amin, Brendan H. Grubbs, Shohreh F. Farzan, Kurunthachalam Kannan, Morgan Robinson, Deborah Lerner, Laila A. Al-Marayati, Daphne K. Walker, Edward G. Grant, Carrie V. Breton, Theresa M. Bastain |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Environmental Advances, Vol 9, Iss , Pp 100286- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2666-7657 |
| DOI: |
10.1016/j.envadv.2022.100286 |
| Popis: |
Background: Perfluoroalkyl substances (PFAS) are ubiquitous synthetic chemicals with long half-lives and are known to cross the placenta during pregnancy. We examined the influence of maternal PFAS levels on in utero fetal growth trajectories and assessed whether maternal stress modified these associations. Methods: Blood serum concentrations of five PFAS (PFOS, PFHxS, PFNA, PFOA, PFDA) were measured in 335 prenatal specimens (mean gestational age (GA): 21±9 weeks) in the MADRES cohort. Fetal growth outcomes (head circumference (HC), abdominal circumference (AC), biparietal diameter (BPD), femur length (FL), and estimated fetal weight (EFW)) were abstracted from ultrasound medical records and measured at the 3rd trimester study visit (N = 833 scans, GA range 10–42 weeks, mean 2.4 scans/participant). Adjusted linear mixed models with a GA quadratic growth curve were used for each PFAS exposure and growth outcome. PFOS and PFHxS were modeled continuously (100% sample detection), while PFOA, PFNA, and PFDA were modeled categorically (57–70% sample detection). Scores on the Perceived Stress Scale (PSS) measured in pregnancy were dichotomized at the median ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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