| Autor: |
Gan B. Bajracharya, Rashmi Koju, Sarbeshwar Ojha, Sashisu Nayak, Sabita Subedi, Hiroaki Sasai |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Results in Chemistry, Vol 3, Iss , Pp 100190- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2211-7156 |
| DOI: |
10.1016/j.rechem.2021.100190 |
| Popis: |
Phthalates are esters of phthalic anhydride. Phthalic anhydride (1) has been reacted with alcohols 2 to synthesize phthalate monoesters 3 and diesters 4 with the favor of latter compound that primarily used as plasticizers worldwide. This two-steps process operates in single pot, in the presence of 10 mol% of FeCl3 as a catalyst. Mechanistically, the first step is the formation of phthalate monoesters 3 that involves a facile addition-displacement pathway, and the second step is essentially underwent a Lewis acid catalysis providing phthalate diesters 4 with very good yields. Application of the present reaction is demonstrated by synthesizing a macrolide 5 through the ring-closing metathesis of diallyl phthalate (4b) using the Grubb’s 2nd generation catalyst. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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