An integrative Bayesian network approach to highlight key drivers in systemic lupus erythematosus

Autor: Samaneh Maleknia, Zahra Salehi, Vahid Rezaei Tabar, Ali Sharifi-Zarchi, Kaveh Kavousi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-12 (2020)
Druh dokumentu: article
ISSN: 1478-6362
DOI: 10.1186/s13075-020-02239-3
Popis: Abstract Background A comprehensive intuition of the systemic lupus erythematosus (SLE), as a complex and multifactorial disease, is a biological challenge. Dealing with this challenge needs employing sophisticated bioinformatics algorithms to discover the unknown aspects. This study aimed to underscore key molecular characteristics of SLE pathogenesis, which may serve as effective targets for therapeutic intervention. Methods In the present study, the human peripheral blood mononuclear cell (PBMC) microarray datasets (n = 6), generated by three platforms, which included SLE patients (n = 220) and healthy control samples (n = 135) were collected. Across each platform, we integrated the datasets by cross-platform normalization (CPN). Subsequently, through BNrich method, the structures of Bayesian networks (BNs) were extracted from KEGG-indexed SLE, TCR, and BCR signaling pathways; the values of the node (gene) and edge (intergenic relationships) parameters were estimated within each integrated datasets. Parameters with the FDR
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