Enhancing Diagnostic Accuracy of aMCI in the Elderly: Combination of Olfactory Test, Pupillary Response Test, BDNF Plasma Level, and APOE Genotype
| Autor: | Yuda Turana, Teguh Asaat S. Ranakusuma, Jan Sudir Purba, Nurmiati Amir, Siti Airiza Ahmad, Moh. Hasan Machfoed, Yvonne Suzy Handayani, Asmarinah, Sarwono Waspadji |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | International Journal of Alzheimer's Disease, Vol 2014 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2090-8024 2090-0252 |
| DOI: | 10.1155/2014/912586 |
| Popis: | Background. Amnestic Mild Cognitive Impairment (aMCI) often progresses to Alzheimer’s disease. There are clinical markers and biomarkers to identify the degenerative process in the brain. Objectives. To obtain the diagnostic values of olfactory test, pupillary response to tropicamide 0.01%, BDNF plasma level, and APOE ε4 in diagnosing aMCI. Methods. Cross-sectional, comparative analysis. Results. There were 109 subjects enrolled (aMCI: 51, normal cognition: 58) with age 64 ± 5.54 years. For diagnosing aMCI, cut-off point for the olfactory score was 22% for pupil dilatation response. Low BDNF plasma level was related significantly with olfactory deficits and aMCI (P |
| Databáze: | Directory of Open Access Journals |
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