Epistemological experience in developing of biomolecular technology for immunogene therapy strategy
| Autor: | Tatiana Castillo, Annabelle Trojan, Maria Claudia Noguera, Lina Manuela Jay, Cecilia Crane, Alexander Shevelev, Alvaro Alvarez, Heliodor Kasprzak, Gonzalo Melo, Pedro Jose Penagos, Beatriz Helena Aristizabal, Ignacio Briceño, Adis Ayala, Huynh T. Duc, Jerzy Trojan |
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| Jazyk: | English<br />Spanish; Castilian |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Revista Científica, Vol 2, Iss 25, Pp 228-240 (2016) |
| Druh dokumentu: | article |
| ISSN: | 0124-2253 2344-8350 |
| DOI: | 10.14483//udistrital.jour.RC.2016.25.a6 |
| Popis: | We have been faced with a 40 year long challenge: how to establish tools that can be applied in the treatment of brain tumor - glioblastoma (100% fatal) - using our knowledge of evolution, chemistry of proteins, genetics, molecular biology and immunology. An efficient strategy targeting growth factor IGF-I, present in tumor development, was established by construction of vectors expressing either IGF-I antisense RNA or IGF-I RNA forming RNA-DNA triple helix. The vectors introduced in the cancer cells in vitro, enable to completely stop the synthesis of IGF-I: on translation or transcription level, respectively. When injected in vivo, these cells induce an immune anti-tumor effect (CD8+) accompanied by increase of the median survival of patients. The first thesis in Colombia describing the used technology, was presented in Distrital University in February 2016. |
| Databáze: | Directory of Open Access Journals |
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