Effect of vitamin D and interferon α-2b on cytokine profile in pregnant women with vaginal infections
| Autor: | M. P. Kostinov, M. A. Ignatieva, S. V. Novikova, A. D. Shmitko, V. B. Polischuk, N. K. Akhmatova, A. A. Savisko, A. M. Kostinov |
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| Jazyk: | ruština |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Инфекция и иммунитет, Vol 10, Iss 3, Pp 524-532 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2220-7619 2313-7398 |
| DOI: | 10.15789/10.15789/2220-7619-EOV-1140 |
| Popis: | A study was conducted to evaluate effectiveness of vitamin D and interferon α-2b preparations on cytokine profile in pregnant women with vaginal infections. It was shown that pregnant women with vs. without bacterial vaginosis were featured with low vitamin D level in 53.8–60.5% cases. Administration of vitamin D and interferon α-2b preparations in combination with antibacterial therapy in pregnant women with bacterial vaginosis conferred anti-inflammatory effect resulting in normalized IL-8 level corresponding to that one in healthy subjects. Use of vitamin D altered interferon status and augmented antimicrobial activity in pregnant women confirmed by reduced rate of ARI episodes. |
| Databáze: | Directory of Open Access Journals |
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