Anti-inflammatory plasma cytokines in children and adolescents with Down syndrome
| Autor: | Joanna Smigielska- Kuzia, Leszek Boækowski, Wojciech Sobaniec, Krzysztof Sendrowski, Beata Żelazowska- Rutkowska, Magdalena Cholewa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Folia Histochemica et Cytobiologica, Vol 48, Iss 4, Pp 667-670 (2010) |
| Druh dokumentu: | article |
| ISSN: | 0239-8508 1897-5631 |
| Popis: | Cytokines participate in many physiological processes including the regulation of immune and inflammatoryresponses. Production of some important cytokines in children with Down syndrome (DS) is depressed or increased . In thisstudy we analysed the selected anti- inflammatory cytokines: interleukin-4 (IL-4), interleukin-10 (IL-10), interleukin-13(IL-13) in plasma of children and adolescents with DS. The study group consisted of 20 patients with Down syndrome and33 healthy subjects at the age of 5-17 years. Levels of: IL-4, IL-10 and IL-13 in plasma samples were determined by specificenzyme- linked immunosorbent assay (ELISA) techniques according to manufacturer's instructions. IL-4 wasdetectable in 25% subjects with Down syndrome and in 28.6% healthy subjects. IL-13 was detectable in 15% patients withDown syndrome and in 15.2% healthy subjects, respectively. IL-10 was detectable in 1 of 20 patients with Down syndromeand in 2 of 33 healthy subjects only. No significant correlations between measurable cytokine levels and age and genderwere found. No significant increased concentration of selected anti- inflammatory cytokines were detected. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|