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Yushan Shi,1 Yanfei Shi,2 Zhangmeng Xu,3 Yan Wang4 1Department of Laboratory, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250000, People’s Republic of China; 2Department of Pulmonary Disease, Dezhou Hospital of Traditional Chinese Medicine, Dezhou, Shanfdong, 253000, People’s Republic of China; 3School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250000, People’s Republic of ChinaCorrespondence: Yan Wang, Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jingshi Road, Lixia District, Jinan, Shandong, People’s Republic of China, Tel +86 159-53182611, Fax +86 531-68616927, Email yan02356@163.comPurpose: This study aims to explore the association between red cell index (RCI) and hospital mortality in Chronic Obstructive Pulmonary Disease (COPD) patients in the intensive care unit.Patients and Methods: This was a retrospective cohort research. The study included 821 COPD patients. Clinical data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database was conducted. Multivariate logistic regression analysis was used to assess the correlation between RCI and in-hospital mortality. Age, SOFA score, diabetes mellitus, cerebrovascular disease, congestive heart failure and mechanical ventilation were considered for subgroup analysis.Results: This study comprised 821 patients, of which 16.5% (124/821) suffered hospital mortality. In the multivariate logistic regression model, RCI was positively associated with hospital mortality, each unit increase in RCI was associated with a 3% increase in hospital mortality (odds ratio [OR] =1.03; 95% confidence interval [95CI%] =1.01– 1.06). Meanwhile, compare with the lowest RCI group, the highest RCI groups tended to have higher risks of hospital mortality (OR [95% CI] 2.33 [1.27– 4.27]). Additionally, subgroup analysis result was persistent among all the groups.Conclusion: Higher RCI was positively associated with a higher risk of mortality in critically ill patients with COPD. Further investigation is necessary to confirm these findings.Keywords: red cell index, chronic obstructive pulmonary disease, hospital mortality, retrospective cohort study, MIMIC-IV |
