| Autor: |
Christoph Schatz, Ludwig Knabl, Hye Kyung Lee, Rita Seeboeck, Dorothee von Laer, Eliott Lafon, Wegene Borena, Harald Mangge, Florian Prüller, Adelina Qerimi, Doris Wilflingseder, Wilfried Posch, Johannes Haybaeck |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Microorganisms, Vol 12, Iss 4, p 798 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2076-2607 |
| DOI: |
10.3390/microorganisms12040798 |
| Popis: |
The global dissemination of SARS-CoV-2 resulted in the emergence of several variants, including Alpha, Alpha + E484K, Beta, and Omicron. Our research integrated the study of eukaryotic translation factors and fundamental components in general protein synthesis with the analysis of SARS-CoV-2 variants and vaccination status. Utilizing statistical methods, we successfully differentiated between variants in infected individuals and, to a lesser extent, between vaccinated and non-vaccinated infected individuals, relying on the expression profiles of translation factors. Additionally, our investigation identified common causal relationships among the translation factors, shedding light on the interplay between SARS-CoV-2 variants and the host’s translation machinery. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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