Role of catestatin in development and decompensation of heart failure: a literature review

Autor: Yu. V. Meshcheryakov, I. V. Gubareva, E. Yu. Gubareva, A. Yu. Alekseeva
Jazyk: ruština
Rok vydání: 2021
Předmět:
Zdroj: Российский кардиологический журнал, Vol 26, Iss 3S (2021)
Druh dokumentu: article
ISSN: 1560-4071
2618-7620
DOI: 10.15829/1560-4071-2021-4492
Popis: The current literature review covers the role of sympathetic nervous system activation (SNS) and the significance of a new biomarker catestatin (CST), which is a chromogranin A-derived peptide, for assessing prognosis of patients with heart failure (HF). This review details the works devoted to CST metabolism and its role in clinical conditions with excessive catecholamine production, including the ability to counterbalance the adverse effects of SNS on cardiovascular system. The paper also presents the central results of studies on HF patients and shows the correlation of the CST level with HF functional class and stage. In addition, particular attention is paid on the possibilities and potential benefits of assessing the CST in addition to conventional management of patients hospitalized due to acute decompensated heart failure.
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