Neurons in the hippocampal CA1 region, but not the dentate gyrus, are susceptible to oxidative stress in rats with streptozotocin-induced type 1 diabetes
| Autor: | Sang Gun Lee, Dae Young Yoo, Hyo Young Jung, Sung Min Nam, Jong Whi Kim, Jung Hoon Choi, Sun Shin Yi, Moo-Ho Won, Yeo Sung Yoon, In Koo Hwang, Seung Myung Moon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
tamoxifen
Src kinase PP2 trauma regeneration neuroprotection auranofin dextromethorphan rosiglitazone Alzheimer′s disease neuroinflammation neurodegeneration microglia astrocytes nerve regeneration spinal cord electroacupuncture therapy neural stem cells notch signaling pathway inflammation survival curve proliferation differentiation real-time quantitative PCR western blot assay neural regeneration superparamagnetic iron oxide magnetic guidance bone marrow mesenchymal stem cells spinal cord injury cell transplantation magnetic resonance image lumbar puncture spinal cord transection average combined score magnetic resonance imaging diffusion tensor imaging fractional anisotropy apparent diffusion coefficient fiber tractography peripheral nerve injury sciatic nerve hypothermia blood-nerve barrier Evans blue tracer neural degeneration polyethyleneimine-polyethylene glycol spiral ganglion cells X-linked inhibitor of apoptosis protein gene therapy nanocarrier cisplatin ototoxicity cochlea ocular hypertension JNK3 retinal ganglion cell glaucoma laser photocoagulation intraocular pressure brain injury apoptosis cerebral ischemia SMAD3 transforming growth factor β1 NSFC grant Chinese herbal formula Tneurotrophic factor ongluo Jiunao injection nerve growth factor receptor Xuesai Tong hippocampus dentate gyrus lipid peroxidation type 1 diabetes malondialdehyde neurons Neurology. Diseases of the nervous system RC346-429 |
| Zdroj: | Neural Regeneration Research, Vol 10, Iss 3, Pp 451-456 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1673-5374 |
| DOI: | 10.4103/1673-5374.153695 |
| Popis: | In this study, we investigated the effects of streptozotocin-induced type 1 diabetes on antioxidant-like protein-1 immunoreactivity, protein carbonyl levels, and malondialdehyde formation, a marker for lipid peroxidation, in the hippocampus. For this study, streptozotocin (75 mg/kg) was intraperitoneally injected into adult rats to induce type 1 diabetes. The three experimental parameters were determined at 2, 3, 4 weeks after streptozotocin treatment. Fasting blood glucose levels significantly increased by 20.7-21.9 mM after streptozotocin treatment. The number of antioxidant-like protein-1 immunoreactive neurons significantly decreased in the hippocampal CA1 region, but not the dentate gyrus, 3 weeks after streptozotocin treatment compared to the control group. Malondialdehyde and protein carbonyl levels, which are modified by oxidative stress, significantly increased with a peak at 3 weeks after malondialdehyde treatment, and then decreased 4 weeks after malondialdehyde treatment. These results suggest that neurons in the hippocampal CA1 region, but not the dentate gyrus, are susceptible to oxidative stress 3 weeks after malondialdehyde treatment. |
| Databáze: | Directory of Open Access Journals |
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