| Autor: |
Yuanchao Zheng, Melanie E. Garrett, Delin Sun, Emily K. Clarke-Rubright, Courtney C. Haswell, Adam X. Maihofer, Jeremy A. Elman, Carol E. Franz, Michael J. Lyons, William S. Kremen, Matthew Peverill, Kelly Sambrook, Katie A. McLaughlin, Nicholas D. Davenport, Seth Disner, Scott R. Sponheim, Elpiniki Andrew, Mayuresh Korgaonkar, Richard Bryant, Tim Varkevisser, Elbert Geuze, Jonathan Coleman, Jean C. Beckham, Nathan A. Kimbrel, Danielle Sullivan, Mark Miller, Jasmeet Hayes, Mieke Verfaellie, Erika Wolf, David Salat, Jeffrey M. Spielberg, William Milberg, Regina McGlinchey, Emily L. Dennis, Paul M. Thompson, Sarah Medland, Neda Jahanshad, Caroline M. Nievergelt, Allison E. Ashley-Koch, Mark W. Logue, Rajendra A. Morey |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2158-3188 |
| DOI: |
10.1038/s41398-021-01707-x |
| Popis: |
Abstract The volume of subcortical structures represents a reliable, quantitative, and objective phenotype that captures genetic effects, environmental effects such as trauma, and disease effects such as posttraumatic stress disorder (PTSD). Trauma and PTSD represent potent exposures that may interact with genetic markers to influence brain structure and function. Genetic variants, associated with subcortical volumes in two large normative discovery samples, were used to compute polygenic scores (PGS) for the volume of seven subcortical structures. These were applied to a target sample enriched for childhood trauma and PTSD. Subcortical volume PGS from the discovery sample were strongly associated in our trauma/PTSD enriched sample (n = 7580) with respective subcortical volumes of the hippocampus (p = 1.10 × 10−20), thalamus (p = 7.46 × 10−10), caudate (p = 1.97 × 10−18), putamen (p = 1.7 × 10−12), and nucleus accumbens (p = 1.99 × 10−7). We found a significant association between the hippocampal volume PGS and hippocampal volume in control subjects from our sample, but was absent in individuals with PTSD (GxE; (beta = −0.10, p = 0.027)). This significant GxE (PGS × PTSD) relationship persisted (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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