| Autor: |
Matheus Henrique Romão, Graziele Freitas de Bem, Izabelle Barcellos Santos, Ricardo de Andrade Soares, Dayane Teixeira Ognibene, Roberto Soares de Moura, Cristiane Aguiar da Costa, Ângela Castro Resende |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 65, Iss , Pp 103726- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2019.103726 |
| Popis: |
The Euterpe oleracea Mart. (açaí) seed extract (ASE), rich in polyphenols, has been evidenced as a potential regulator of body mass with antioxidant and anti-inflammatory actions. We aimed to assess the effects of ASE and enalapril (ENA) on the hepatic steatosis and fibrosis and related overexpressed RAS, oxidative stress and inflammation in C57BL/6 mice fed a high-fat diet (HFD). The animals were fed a standard diet (10% fat, Control), 60% fat (HF), HF + ASE (300 mg kg−1 d−1) and HF + ENA (30 mg kg−1 d−1) for 12 weeks. Our results demonstrate that ASE prevented the obesity and related hepatic steatosis and fibrosis in HFD-fed mice. The negative modulation of RAS in hepatic tissue may contribute to these beneficial effects of ASE by favoring the reduction of the oxidative stress and inflammation, highlighting a greater antioxidant activity of ASE compared to ENA. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect