| Autor: |
Fady B. Geara, Muhammad Bulbul, Raja B. Khauli, Therese Y. Andraos, Mirna Abboud, Abdelatif Al Mousa, Nasim Sarhan, Ahmed Salem, Hamza Ghatasheh, Anoud Alnsour, Zeina Ayoub, Ibrahim Abu Gheida, Maya Charafeddine, Mohammed Shahait, Ali Shamseddine, Rami Abu Gheida, Jamal Khader |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Radiation Oncology, Vol 12, Iss 1, Pp 1-8 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1748-717X |
| DOI: |
10.1186/s13014-017-0884-y |
| Popis: |
Abstract Background The aim of this study is to investigate the effect of tumor characteristics and parameters of treatment response in predicting biochemical disease-free survival (BFS) for patients with intermediate or high risk prostate cancer treated by combined definitive external beam radiation therapy (EBRT) and androgen deprivation therapy (ADT). Methods Between June 1995 and January 2015, 375 patients with localized prostate cancer and a National Comprehensive Cancer Network (NCCN) intermediate or high risk categories were treated by definitive EBRT and ADT. Median duration of androgen blockade was 10 months (range: 3–36 months); Median radiation dose was 72 Gy (Range: 70–78 Gy). Median follow-up time was 5.8 years (range: 0.8–16.39 years). The main study endpoint was biochemical disease free survival (BFS). Results Forty seven patients (12.5%) developed biochemical recurrence (BCR) during the observation period. Monovariate analysis identified baseline PSA (bPSA) (p = 0.024), T-stage (p = 0.001), Gleason’s score (GS) (p = 0.042), radiation dose (p = 0.045), PSA pre-radiation therapy (p = 0.048), and nadir PSA (nPSA), (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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