Targeting myomiRs by tocotrienol-rich fraction to promote myoblast differentiation

Autor:	Azraul Mumtazah Razak, Shy Cian Khor, Faizul Jaafar, Norwahidah Abdul Karim, Suzana Makpol
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Muscle Myoblast MicroRNA Gene expression Tocotrienol Cell differentiation Nutrition. Foods and food supply TX341-641 Genetics QH426-470
Zdroj:	Genes & Nutrition, Vol 13, Iss 1, Pp 1-14 (2018)
Druh dokumentu:	article
ISSN:	1555-8932 1865-3499
DOI:	10.1186/s12263-018-0618-2
Popis:	Abstract Background Several muscle-specific microRNAs (myomiRs) are differentially expressed during cellular senescence. However, the role of dietary compounds on myomiRs remains elusive. This study aimed to elucidate the modulatory role of tocotrienol-rich fraction (TRF) on myomiRs and myogenic genes during differentiation of human myoblasts. Young and senescent human skeletal muscle myoblasts (HSMM) were treated with 50 μg/mL TRF for 24 h before and after inducing differentiation. Results The fusion index and myotube surface area were higher (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/93ca0dcf76f54cd99e8380532f456751 Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ