| Autor: |
Lu Lu, Lin-Lei Chen, Ricky Rui-Qi Zhang, Owen Tak-Yin Tsang, Jacky Man-Chun Chan, Anthony Raymond Tam, Wai-Shing Leung, Thomas Shiu-Hong Chik, Daphne Pui-Ling Lau, Chris Yau-Chung Choi, Carol Ho-Yan Fong, Jian-Piao Cai, Hoi-Wah Tsoi, Charlotte Yee-Ki Choi, Xiaojuan Zhang, Syed Muhammad Umer Abdullah, Brian Pui-Chun Chan, Kwok-Hung Chan, Kwok-Yung Yuen, Ivan Fan-Ngai Hung, Kelvin Kai-Wang To |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
EBioMedicine, Vol 79, Iss , Pp 103986- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2352-3964 |
| DOI: |
10.1016/j.ebiom.2022.103986 |
| Popis: |
Summary: Background: SARS-CoV-2 Omicron variant evades immunity from past infection or vaccination and is associated with a greater risk of reinfection among recovered COVID-19 patients. We assessed the serum neutralizing antibody (NAb) activity against Omicron variant (Omicron NAb) among recovered COVID-19 patients with or without vaccination. Methods: In this prospective cohort study with 135 recovered COVID-19 patients, we determined the serum NAb titers against ancestral virus or variants using a live virus NAb assay. We used the receiver operating characteristic analysis to determine the optimal cutoff for a commercially-available surrogate NAb assay. Findings: Among recovered COVID-19 patients, the serum live virus geometric mean Omicron NAb titer was statistically significantly higher among BNT162b2 recipients compared to non-vaccinated individuals (85.4 vs 5.6,P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
