Differential expression of bovine major acute phase proteins, cytokines and metabolic indicator genes in clinical endometritis cows
| Autor: | AYYASAMY MANIMARAN, ARUMUGAM KUMARESAN, SOUVENDRA NATH SARKAR, SANJANNA BOYA, L SREELA, P MOOVENTHAN, PRATIK R WANKHADE |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Indian Journal of Animal Sciences, Vol 89, Iss 4 (2019) |
| Druh dokumentu: | article |
| ISSN: | 0367-8318 2394-3327 |
| DOI: | 10.56093/ijans.v89i4.89139 |
| Popis: | Among the uterine diseases, clinical endometritis (CE) is a major challenge to livestock farming as it causes sub- or infertility problems in dairy animals. The aim of this study was to evaluate the expression of cytokines (IL- 1β, TNF-α, IL-6, and IL-8), acute phase proteins [APPs; haptoglobin (Hp), serum amyloid A (SAA) and alpha-1 acid glycoprotein (AGP)] and energy indicators [leptin and insulin-like growth factor (IGF)-1] genes in uterine tissue of CE affected cows. The uterine biopsy from CE cows (4) and non-endometritis cows (4) was processed for quantitative real-time PCR to study the mRNA expression of these innate immune molecules. We observed that mRNA expression of SAA, IL-1β, IL-8 and leptin genes were significantly up-regulated while, TNF-α and IGF-I genes were significantly down-regulated in CE cows. It can be concluded that bovine APPs, cytokines and energy indicators genes are differentially expressed in CE affected cows. |
| Databáze: | Directory of Open Access Journals |
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