The Emerging Role of NaF-PET/CT in Detecting Vascular Microcalcification in the Pathogenesis of Neurological Dysfunction

Autor: Eric M. Teichner, Robert C. Subtirelu, Arjun B. Ashok, Yvonne Su, Victoria A. Anderson, Milo Writer, Omar Al-Daoud, Miraziz Ismoilov, William Y. Raynor, Thomas J. Werner, Poul F. Høilund-Carlsen, Abass Alavi, Mona-Elisabeth Revheim
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Vascular Diseases, Vol 2, Iss 3, Pp 310-316 (2023)
Druh dokumentu: article
ISSN: 2813-2475
DOI: 10.3390/jvd2030023
Popis: Cerebrovascular disease (CVD) is a global health concern, and early detection is crucial for effective intervention. This case report presents a 31-year-old male patient with multiple cardiac risk factors who underwent positron emission tomography/computed tomography (PET/CT) with 18F-sodium fluoride (NaF) and 18F-fluorodeoxyglucose (FDG) to evaluate for the presence and degree of atherosclerosis in the aorta, carotid arteries, coronary arteries, iliac arteries, and the femoral arteries. Elevated NaF uptake within the bilateral carotid arteries signified substantial ongoing vascular microcalcification. Reduced global brain metabolism and region-specific hypometabolism measured with FDG PET indicated potential cerebrovascular mechanisms that may be influencing neurological function. The findings highlight the potential of emerging PET tracers, such as NaF, to improve the diagnostic accuracy and therapeutic management of CVD. This case emphasizes the importance of a comprehensive diagnostic approach as well as continued investigation into CVD pathophysiology using PET-based techniques, which may guide the development of innovative therapeutic strategies.
Databáze: Directory of Open Access Journals