Fatal pulmonary Scedosporium aurantiacum infection in a patient after near-drowning: A case report
| Autor: | Roya Ghasemian, Azadeh Bandegani, Firoozeh Kermani, Leila Faeli, Behrad Roohi, Elham Yosefi Abdolmaleki, Mohammad T. Hedayati, Emmanuel Roilides, Tahereh Shokohi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Current Medical Mycology, Vol 7, Iss 4, Pp 38-42 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2423-3439 2423-3420 |
| DOI: | 10.18502/cmm.7.4.8410 |
| Popis: | Background and Purpose: Scedosporium spp. is a saprophytic fungus that may cause invasive pulmonary infection due to the aspiration of contaminated water in both immunosuppressed and immunocompetent hosts.Case report: Herein, we report a fatal case of pulmonary infection caused by Scedosporium species associated with a car crash and near-drowning in a sewage canal.Scedosporium aurantiacum isolated from bronchoalveolar lavage was identified by PCR-sequencing of β-tubulin genes. The minimum inhibitory concentration values for amphotericin B, itraconazole, posaconazole, isavuconazole were >16 µg/ml, and >8 µg/ml for anidulafungin, micafungin, and caspofungin. Voriconazole was found to be the most active agent with a MIC of 1 µg/ml.Conclusion: This report, as the first case of pulmonary scedosporiosis after near-drowningin Iran, highlights the importance of high suspicion in near-drowning victims, promptidentification of Scedosporium spp., and early initiation of appropriate antifungal therapy. |
| Databáze: | Directory of Open Access Journals |
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