Peutz-Jeghers Type Polyp of the Appendix with Review of Literature

Autor: Jolanta Jedrzkiewicz, Keith Quencer, Anna P. Matynia, Ellen Morrow, Maria Pletneva, Gonzalo Barraza
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Case Reports in Pathology, Vol 2019 (2019)
Druh dokumentu: article
ISSN: 2090-6781
2090-679X
DOI: 10.1155/2019/7584070
Popis: Hamartomatous polyps of Peutz-Jeghers type are strongly associated with Peutz-Jeghers polyposis syndrome and are predominantly encountered in the small intestine. Sporadic cases are uncommonly reported. We report a case of a polyp identified incidentally in the appendix of a patient undergoing diagnostic imaging due to a history of hepatitis C infection. Histopathologic evaluation after appendectomy showed a polyp with bands of muscularis mucosae bundles with arborizing architecture and variable amounts of inspissated mucin, morphologically indistinguishable from Peutz-Jeghers type hamartomatous polyp. A family or personal history of abdominal cancers was not reported by the patient, suggesting a sporadic occurrence. Next generation sequencing revealed only two pathogenic low-level STK11 mutations, presumed to be somatic. In conclusion, this is an unusual case of a sporadic Peutz-Jeghers type polyp occurring in the appendix.
Databáze: Directory of Open Access Journals
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