Pro-Oxidants and Antioxidants in Retinopathy of Prematurity
| Autor: | Lidija Banjac, Goran Banjac, Jelena Kotur-Stevuljević, Vesna Spasojević-Kalimanovska, Tamara Gojković, Nataša Bogavac-Stanojević, Zorana Jelić-Ivanović, Gorica Banjac |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Acta Clinica Croatica, Vol 57., Iss 3., Pp 458-463 (2018) |
| Druh dokumentu: | article |
| ISSN: | 0353-9466 1333-9451 |
| DOI: | 10.20471/acc.2018.57.03.08 |
| Popis: | Premature infants are susceptible to oxidative stress that causes neonatal disease such as retinopathy of prematurity (ROP). Oxidative stress is an imbalance between the production of pro-oxidants and the ability of the body to detoxify their harmful effects by antioxidants. The proliferative phase 2 ROP occurs at around 33rd postmenstrual week (pmw). The purpose of our study was to evaluate the pro-oxidant/antioxidant status in preterm infants at 33rd pmw. The study included 59 premature infants. ROP was classified according to the International Classification of Retinopathy of Prematurity. Total oxidative status (TOS), total antioxidant status (TAS), malondialdehyde (MDA) and paraoxonase 1 (PON1) activity were determined spectrophotometrically. The values of the pro-oxidants TOS and MDA were significantly higher in infants with ROP as compared to infants without ROP (p |
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