| Popis: |
We reported in article da Silva et al. (2016) [2] that ArtinM induces the IL-17 production through interaction with CD4+ T cells and stimulation of IL-23 and IL-1. Besides ArtinM, other plant lectins (PLs) induce IL-17 production by murine spleen cells. The IL-17 production induced by PLs was evaluated regarding the involvement of IL-23, IL-6, Th1-, and Th2-cytokines. Furthermore, the effect exerted TLR2, TLR4, and CD14 on the PLs׳ performance in the induction of IL-17 was examined. The current data were compared to the known ArtinM ability to induce Th17 immunity. Keywords: IL-17, Plant lectins, ArtinM, Carbohydrate recognition, Immunomodulation |
