| Autor: |
Di Wang, Guangrong Zhu, Na Wang, Xiaoxi Zhou, Yunfan Yang, Shiqiu Zhou, Jie Xiong, Jing He, Lijun Jiang, Chunrui Li, Danmei Xu, Liang Huang, Jianfeng Zhou |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 8, Iss 9, p e73865 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0073865 |
| Popis: |
SIL-TAL1 rearrangement is common in T-cell acute lymphoblastic leukemia (T-ALL), however its prognostic implication remains controversial. To investigate the clinical characteristics and outcome of this subtype in Chinese population, we systemically reviewed 62 patients with newly diagnosed T-ALL, including 15 patients with SIL-TAL1 rearrangement. We found that SIL-TAL1(+) T-ALL was characterized by higher white blood cell count (P = 0.029) at diagnosis, predominant cortical T-ALL immunophenotype (P = 0.028) of the leukemic blasts, and a higher prevalence of tumor lysis syndrome (TLS, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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