Corifollitropin alfa for poor responders patients, a prospective randomized study

Autor: F. M. Fusi, L. Zanga, M. Arnoldi, S. Melis, M. Cappato, I. Candeloro, A. Di Pasqua
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Reproductive Biology and Endocrinology, Vol 18, Iss 1, Pp 1-6 (2020)
Druh dokumentu: article
ISSN: 1477-7827
DOI: 10.1186/s12958-020-00628-6
Popis: Abstract Background Poor ovarian response remains one of the biggest challenges for reproductive endocrinologists. The introduction of corifollitropin alpha (CFA) offered an alternative option to other gonadotropins for its longer half-life, its more rapid achievement of the threshold and higher FSH levels. We compared two different protocols with CFA, a long agonist and a short antagonist, and a no-CFA protocol. Methods Patients enrolled fulfilled at least two of the followings: AFC 40 years. Ovarian stimulation with an antagonist protocol was performed either with 300 UI rFSH and 150 UI rLH or 300UI HMG. In the long agonist group, after pituitary suppression with triptorelin, CFA was given the 1-2th day of cycle and 300 UI rFSH and 150 UI rLH the 5th day. In the short antagonist group CFA was given the 1-2th day of cycle and 300 UI rFSH and 150 UI rLH the 5th day. The primary objective was the effect on the number of oocytes and MII oocytes. Secondary objective were pregnancy rates, ongoing pregnancies and ongoing pregnancies per intention to treat. Results The use of CFA resulted in a shorter lenght of stimulation and a lower number of suspended treatments. Both the CFA protocols were significantly different from the no-CFA group in the number of retrieved oocytes (p
Databáze: Directory of Open Access Journals
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