Anti-GPVI (HY101) activates platelets in a multicolor flow cytometry panel

Autor:	Marie-Astrid van Dievoet, Davide Brusa, Marie Octave, Sandrine Horman, Xavier Stephenne
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	anti-gpvi flow cytometry hy101 platelet Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Platelets, Vol 33, Iss 7, Pp 1096-1099 (2022)
Druh dokumentu:	article
ISSN:	0953-7104 1369-1635 09537104
DOI:	10.1080/09537104.2022.2027359
Popis:	The platelet transmembrane receptor GPVI can be assessed together with other platelet membrane markers in a whole blood multicolor flow cytometry panel. The advantage of combining multiple antibodies in a single tube is the possibility of distinguishing multiple platelet subgroups. In this short communication, we describe an activation problem encountered with anti-GPVI, clone HY101. Activation of platelets was seen after the addition of anti-GPVI in a flow cytometry panel, highlighted by the expression of the activation markers CD62P, PAC-1, CD63, and CD107a. This was also confirmed by platelet aggregation studies.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8f9fe7c2e11d40f0b1f7f3e1b58ec5af Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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