| Autor: |
Nan Chen, Yan Chen, Fenghua Lai, Li Chen, Rui Zeng, Ling Pei, Liting Wu, Chenxue Wang, Yanbing Li, Haipeng Xiao, Xiaopei Cao |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
International Journal of Endocrinology, Vol 2022 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1687-8345 |
| DOI: |
10.1155/2022/4203018 |
| Popis: |
The sympathoadrenal system has been shown to stimulate the secretory activity of enteroendocrine cells, although the response is transient. Our aim was to investigate the effects of long-term catecholamine excess on circulating glucagon-likepeptide-1 (GLP-1) levels in patients with pheochromocytoma/paraganglioma (PPGL). Thirty patients diagnosed with PPGL were analyzed. A significant negative association was observed between fasting plasma GLP-1 levels and elevated plasma-free metanephrine (r=−0.407,p=0.026). After adjustment for age, sex, body mass index (BMI), serum creatinine, and the presence of hyperglycemia, the negative association between plasma GLP-1 and metanephrine persisted by multiple linear regression analysis (β=−0.493,p=0.013). Positive correlations between fasting glucose and plasma metanephrine (r=0.380,p=0.038) and normetanephrine levels (r=0.450,p=0.013) were also found. Mean fasting levels of total GLP-1 increased significantly from 25.81 to 39.01 pmol/L (p=0.017) after PPGL resection. In conclusion, long-term overproduction of catecholamines appears to induce suppression of GLP-1 production compared to an acute response to a stress stimulus. Further studies are required to elucidate the mechanism of GLP-1 secretion with chronic exposure to catecholamine. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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