| Autor: |
Jason R. Hickok, Divya Vasudevan, Kate Jablonski, Douglas D. Thomas |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Redox Biology, Vol 1, Iss 1, Pp 203-209 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
2213-2317 |
| DOI: |
10.1016/j.redox.2012.11.002 |
| Popis: |
Nitric oxide (·NO) is a biologically important short-lived free radical signaling molecule. Both the enzymatic synthesis and the predominant forms of cellular metabolism of ·NO are oxygen-dependent. For these reasons, changes in local oxygen concentrations can have a profound influence on steady-state ·NO concentrations. Many proteins are regulated by ·NO in a concentration-dependent manner, but their responses are elicited at different thresholds. Using soluble guanylyl cyclase (sGC) and p53 as model ·NO-sensitive proteins, we demonstrate that their concentration-dependent responses to ·NO are a function of the O2 concentration. p53 requires relatively high steady-state ·NO concentrations (>600 nM) to induce its phosphorylation (P-ser-15), whereas sGC responds to low ·NO concentrations ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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