Constituents from the Seeds of Sophora Alopecuroides L.

Autor: Zi-Jian Rong, Gao-Sheng Hu, Shi-Yi Lin, Ting Yan, Na Li, Yue Zhao, Jing-Ming Jia, An-Hua Wang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Molecules, Vol 25, Iss 2, p 411 (2020)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules25020411
Popis: Three new isoflavone glucosides, kudonol A−C (1−3), two new ester derivatives of phenylpropanoid, kudolignan A and B (4−5) and five known compounds, (−)-maackiain (6), neoliquiritin (7), methyl 4-coumarate (8), methyl ferulate (9) and (+)-wikstromol (10), were isolated from an extract of dried seeds of the traditional Chinese medicinal plant Sophora alopecuroides L. Their structures were established by NMR and HRESIMS data analyses. The monosaccharide part’s configuration of isoflavone glucosides was confirmed by acid hydrolysis and analyzed by a JAsco OR-4090 chiral detector, comparing it to standard substance D-glucose. The cytotoxicity effects against HeLa, Hep3B, MCF-7 and H1299 cells were tested by CCK-8 assay.
Databáze: Directory of Open Access Journals
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