| Autor: |
Daniela Viecceli, Mariana Pires Garcia, Laiana Schneider, Ana Paula Alegretti, Cristiano Kohler Silva, André Lucas Ribeiro, Claiton Viegas Brenol, Ricardo Machado Xavier |
| Jazyk: |
English<br />Spanish; Castilian<br />Portuguese |
| Předmět: |
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| Zdroj: |
Revista Brasileira de Reumatologia, Vol 57, Iss 5, Pp 385-391 |
| Druh dokumentu: |
article |
| ISSN: |
1809-4570 |
| DOI: |
10.1016/j.rbre.2016.09.007 |
| Popis: |
Abstract Objectives: To correlate the basal expression of complement regulatory proteins (CRPs) CD55, CD59, CD35, and CD46 in B-lymphocytes from the peripheral blood of a cohort of 10 patients with rheumatoid arthritis (RA) initiating treatment with rituximab (RTX) with depletion and time repopulation of such cells. Methods: Ten patients with RA received two infusions of 1 g of RTX with an interval of 14 days. Immunophenotypic analysis for the detection of CD55, CD59, CD35, and CD46 on B-lymphocytes was carried out immediately before the first infusion. The population of B-lymphocytes was analyzed by means of basal CD19 expression and after 1, 2, and 6 months after the infusion of RTX, and then quarterly until clinical relapse. Depletion of B-lymphocytes in peripheral blood was defined as a CD19 expression |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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